Given the lack of individual preclinical models of PCOS that recapitulate all the metabolic, endocrine, and gonadal traits of the clinical syndrome, pharmacological testing was conducted in parallel in these two PCOS models, which are among the most reliable to mimic the metabolic and gonadal phenotype of women with PCOS 36,37 , capturing also the heterogeneity of this condition 38
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Most participants who experience GI symptoms during the first 20 weeks report minimal or no symptoms by month 12
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Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge