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In short, cGMP imposes a strict human-centric control framework : all manufacturing processes and records must be defined, implemented, and reviewed by authorized personnel in accordance with documentation and validation requirements

35 Nausea can be addressed in several of different ways: if receiving a titratable GLP-1RA, return to the previous dose or premeal interval that did not cause symptoms (maximal tolerated dose) give a nontitratable GLP-1RA on a full stomach consider antiemetics for intractable symptoms

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*Correspondence: Maria Paula Macedo, [email protected] This article was submitted to Molecular Medicine, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers