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Research reveals that senescent cells show upregulation of pro-apoptotic initiators PUMA and BIM while anti-apoptotic guardian BCL-2 is reduced, suggesting these cells are ready to undergo apoptosis but the execution is restrained by the FOXO4-p53 interaction

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Ismail-Beigi F, Craven T, Banerji MA, Basile J, Calles J, Cohen RM, et al

This makes them the commonly discussed for digestive support because it contacts the gastrointestinal lining