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When urine is concentrated, it can become more irritating to the bladder and urethra, potentially causing a burning or painful sensation during urination
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Toxicol Mech Methods 24:703712
SIRT1, localized in the nucleus, deacetylases and activates proliferator-activated receptor gamma coactivator-1 (PGC-1), which leads to increased mitochondrial biogenesis 103
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