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In addition, except for two patients whose time to ADR onset was unknown and one patient who developed ADR symptoms within 1 week, ADR onset occurred over several weeks in the remaining 17 patients, with the longest reported duration being 5 months

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M.DAlessioD.GrewalD

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Importantly, overall exposure to the drug (measured as area under the curve, or AUC) was not significantly changed

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Its important to be aware of the risk factors and to maintain a balanced diet rich in vitamin B12-containing foods or supplements if necessary, especially for individuals at higher risk of deficiency

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