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This selectivity is important because it suggests the compound affects only its intended target rather than causing widespread metabolic disruption

Disadvantages of using oral forms: inferior absorption, inferior cellular activity, require high compliance with daily dosing

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We first observed, in a previously published bulk RNA-seq dataset of MEFs undergoing in vitro reprogramming 40 , that Mtr and Cd320 were upregulated soon after OSKM induction, remaining high during the early and middle phases of reprogramming, ultimately stabilizing to levels above those measured in MEFs (Extended Data Fig