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Under conditions of aging or mechanical stressboth well-established OA risk factorsMQC dysfunction may trigger mitochondrial ROS overproduction and mtDNA damage

Understanding the answer requires a little science and some common sense

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Aging Smoking and alcohol use Chronic illness or inflammation Poor diet or inadequate protein intake Environmental toxin exposure Sleep deprivation and prolonged stress Can low glutathione cause symptoms

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Chow DJX, Tan TCY, Upadhya A, et al