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Current Phase 2 clinical trial data have not identified depression as a confirmed side effect of retatrutide, though longer-term Phase 3 evidence is still awaited
Changes in energy, clothing fit, mobility, and body composition are equally important
Maintenance : Continued use of semaglutide and lifestyle changes can help maintain weight loss over time
Side effects compared All three oral GLP-1s share a similar side-effect profile because they act on the same hormone receptor (they mimic GLP-1)
Vitamin D deficiency was the most common, followed by low iron and B-complex vitamins
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