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Morphologically, degeneration and death of astrocytes are known as clasmatodendrosis (from Greek , fragment, , tree, , process), described, for the first time, by Alois Alzheimer, who found disintegrating, fragmented processes of astrocytes and oligodendrocytes in epilepsy, neurosyphilis and dementia

Endogenous creatine synthesis also consumes methyl groups, so high creatine demand may place additional pressure on SAM-dependent methylation

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