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Beyond their primary indications in treating type 2 diabetes and high BMI, these medications have demonstrated potential benefits in addressing many of the conditions associated with NAION including hypertension, hyperlipidemia and obstructive sleep apnea, they wrote, likely as a result of their weight loss effects

Interestingly, that PLC can act either as an oncogene or as a tumor suppressor for different tumor entities (Table 1, Figure 4)

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Fatigue affects 5-11% of patients and typically results from substantial caloric restriction due to appetite suppression, gastrointestinal side effects like nausea and vomiting, dehydration from reduced oral intake, or rapid metabolic changes during weight loss

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The recommendations below are synthesized from ipamorelin's known pharmacology, GH axis physiology in liver disease, and general FDA guidance on peptide dosing in organ impairment