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In some experiments, we applied receptor antagonists, an ion channel antagonist or a phosphodiesterase inhibitor to the organ baths as delineated in the figure legends and in Table 1

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This experiment more comprehensively revealed the mechanism of berberine acting on GLP-1/GLP-1R/PKA signal pathway, and also showed that islet cell probably play an important role in the treatment of T2DM, providing some ideas for the follow-up study of islet function