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"While these changes are most pronounced on the face, they can also be seen in other parts of the body, including neck and buttocks, with sagging and wrinkling." GLP-1 medications may also contribute to hormonal and metabolic changes that can affect rapidly growing tissues like hair and nails

GLP-1 has one of the most extensive published research bases of any peptide hormone in modern biomedical science, with thousands of peer-reviewed studies spanning its discovery, physiology, receptor pharmacology, and the entire GLP-1RA drug class built upon it

J Neurochem 84:11731183 Anderson ME, Luo JL (1998) Glutathione therapy: from prodrugs to genes

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While this class of medications is generally considered safe and effective, potentially severe neurological complications may be associated with rapid weight loss and nutritional deficiencies following GLP-1 agonist use

ACTH triggers cortisol release from the adrenal glands