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Research also suggests that a better quality dietary lifestyle can help reduce the severity of GLP-1 side effects more broadly, with complementary nutritional strategies shown to address gastrointestinal adverse effects, support lean mass preservation, and improve long-term adherence
The largest trial of ERAs, SONAR, including 2648 participants with type 2 diabetes and proteinuric CKD, demonstrated that atrasentan on top of RAS inhibition significantly lowered the risk of a doubling of serum creatinine or ESKD compared with placebo by 35% [75]
These medications improve several metabolic health markers: Lower blood pressure Improved cholesterol profiles Reduced inflammation markers 8 Modest 5-7% weight loss significantly reduces type 2 diabetes risk 6
