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Brain energy metabolism: a roadmap for future research

The sweet spot is 500 mg daily, taken via oral supplementation

In vitro experiments demonstrated that Akt inhibition markedly upregulated the expression of FTL, FTH, TFR1, and Poly (rC)-binding protein 1 (PCBP1), downregulated FPN1 expression, increased APP expression, enhanced iron storage and uptake, and decreased iron efflux, thereby aggravating neurological injury in SH-SY5Y and C2C12 cells (Halon-Golabek et al., 2024)

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Typically, the initial discomfort dissipates quickly