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Also, the healthcare provider will determine the appropriate B12 dosage, depending on the current medical condition and diet

Adjusted regression analysis indicated an approximately 1% additional monthly BMI reduction with GLP-1 therapy ( = 1.08%, p = 0.001)

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Overall, compared with the large and growing amount of pre-clinical and mechanistic evidence highlighting the reward-modulating and thus potentially anti-addictive properties of GLP-1RAs, only a few studies have investigated thus far the potential use of these medications in clinical populations with alcohol- or other substance-use disorders