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Unfortunately, studies on this topic have mainly focused on normalising serum B12 concentrations with oral supplementation and should be interpreted with caution since the specific goal of treatment in symptomatic B12 deficiency is alleviating symptoms, and NOT to normalize B12 concentrations in the blood

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this makes supplementation an attractive option for those focused on longevity, skin clarity, and optimal health

To explore the effect of the TRIM28 double-KR mutation on PGC development, we first generated a K774R + K779R AG-haESC line based on Blimp1-T2A-Cre cells (Fig