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Therefore, future clinical translation will probably benefit from biomarker-guided frameworks, incorporating (1) FSP1 abundance/localization, (2) CoQ pool size and redox state, (3) lipid peroxidation signatures and (4) metabolic context (mitochondrial activity and sulfur/selenium flux)
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However, it is widely accepted that HO-1 is a heat shock protein that is controlled by inflammatory or pro-oxidant states and is induced in various pathologies in response to oxidative stress [1]