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Shorb knew that the same liver extract was used to treat pernicious anemia (her father-in-law had died from the disease), and concluded that LLD could be developed as an assay method to identify the active compound
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Their investigations into EPOs non-hematopoietic signaling led to the design of shorter peptide fragments including ARA-290 that retain tissue-protective activity while avoiding erythropoietic side effects
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10.1016/j.curtheres.2014.01.001 58 Tuba-KartalA.ala-MutluZ
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