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Significant interference from relevant biomarkers GLP-1 analogues can regulate insulin levels, and co-administration of both GLP-1 analogues and basal insulin can offer complementary pharmacological properties

Inflammatory cell infiltration in adipose tissue, muscle, pancreas, and liver due to a saturated fatty acid diet, obesity, and elevated levels of inflammatory cytokines such as tumor necrosis factor, IL-1, and IL-6 result in persistent chronic low-grade inflammation (62, 63)

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Emerging evidence suggests they alter food cue reactivity, reward signaling, and addictive behaviors, while leaving key questions about mood and emotional eating unresolved

Its Phase 2 weight loss data (24.2% at 48 weeks) and mechanistic advantages in hepatic fat reduction through glucagon receptor activation suggest it could surpass semaglutide's efficacy if Phase 3 results confirm the Phase 2 findings

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