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This was supported by another study in which liraglutide attenuated the TNF or high-glucose-mediated induction of PAI-1, ICAM-1, and VCAM-1 expression in human vascular endothelial cells, the proposed molecular mechanism underlying this effect may involve the regulation of NUR77 expression [61], which is a nuclear receptor and transcription factor involved in regulating gene expression related to cell growth, apoptosis, metabolism, and inflammation
EP and KK drafted the manuscript
Evidence and current limitations. Fella Health, 2024
However, like all medications, they may be associated with certain side effects, such as gastrointestinal issues, including nausea, vomiting, diarrhea, and constipation
Some individuals progress through standard dosing, while others may need adjustments for faster results, fewer side effects, or better long-term maintenance
Recent research indicates that semaglutide can be highly effective here
