(2,3) Mycotoxins have also been shown to impair glutathione recycling, disrupt NRF2-mediated antioxidant signaling, and increase oxidative stress burden, further compromising mitochondrial efficiency and redox balance
New York, NY: Taylor & Francis
Currently, there is no evidence to recommend IV glutathione as a skin-lightening agent
The risk, however, lies less with the molecule itself than with the quality of the preparation and the conditions of administration: a cluster of seven cases of endotoxin poisoning was described after infusions prepared from contaminated raw material not intended for intravenous use (Johnstone et al., Epidemiology and Infection 2018, PMID 29673413)
Individual compound references available on PubChem
Front Pharmacol 9:511 Zhu C, Blakely R, Hewlett W (2006) The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters