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Given the observation of similar developmental toxicity of the cytosolic and mitochondrial Grx1-roGFP2 variants, the greater R/R 0 dynamic range in Grx1- versus mito-Grx1-roGFP2 cells, and our ultimate goal to establish proof-of-concept for in-tissue GSH/GSSG imaging, we decided to focus on the cytosolic Grx1-roGFP2 variant in the following experiments

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Additional hyperglycemia slightly exacerbates acidosis within the core, since only the glucose present at the onset of ischemia can be metabolized

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