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The researchers administered 2.4 mg subcutaneous semaglutide (Wegovy, Novo Nordisk) once weekly to patients with obesity and moderate knee OA, who had at least moderate pain, and compared their outcomes with a placebo group over 68 weeks

2 Symptoms May Become Noticeable Again For some patients, Month 2 may include a prescribed dose increase

doi: 10.1038/s41598-025-92733-y, 18

In Study 3 missing values for Week 56 were handled using weighted regression analysis

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Tirzepatide will also help answer the question whether substantial effects on both plasma glucose and body weight together can prevent diabetes complications better than only lowering blood sugar