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While the Fe-S cluster is critical for activity, its role for the reaction mechanism remains unclear ( in vitro using glutathione disulfide (GSSG) or in vivo in response to ozone and paraquat, and inactivated upon reduction ( Four APK proteins exist in Arabidopsis, APK1, 2, and 4 locate in plastids whereas APK3 is in the cytosol (Mugford et al., 2009)
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This allows the detection of genes that are consistently enriched or depleted for the majority of the sgRNAs designed for each gene
By binding less strongly to these proteins, IGF-1 LR3 may remain more available to interact with cellular receptors in experimental contexts
doi: 10.26355/eurrev_202210_30023 65
Genetic associations with glucose and HbA1c were obtained from UK Biobank and also a large consortium mainly in Europeans, MAGIC (140,595 people without diabetes for glucose [33] and 145,579 for HbA1c [34])
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