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Due to their poor bioavailability when administered orally, peptide therapies typically require injection, which can impact on adherence, particularly in chronic diseases where long-term treatment is needed [2, 5,6,7]
Curr Opin Investig Drugs
More damaged tissue = longer therapeutic activity Mild inflammation = shorter duration of action This is why users healing from surgery or major soft tissue injuries may feel benefits weeks after their last dose
Life changes sometimes require breaks from medication
Saxenda - 2.0% citation share - GLP-1 / Pharmaceutical (declining as weekly options expand) 12
Second Natures peer-reviewed research directly compared both medications when combined with behavioural support, finding Mounjaro users lost 22.1% of their starting weight while Wegovy (up to 2.4 mg) users lost 17.1% at 12 months
