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These effects appear to be mediated through modulation of dopamine signaling in the mesolimbic reward system in animal models, potentially dampening the reinforcing properties of addictive substances

It's helped her lose almost 50 pounds in 17 months, weight she struggled to lose through traditional dieting and exercise

Combine this with all the other factors conspiring to put the lost weight back on, and you can end up potentially becoming even fatter than they were to begin with

For people whose primary concern is metabolic health rather than maximum weight loss, dulaglutide deserves consideration

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