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AOD9604 is a synthetic 15amino acid peptide fragment derived from the Cterminal region of human growth hormone (amino acids 176191)

1 Introduction The field of ferroptosis research has experienced significant expansion in recent years since the term was introduced in 2012

Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S

It has gained significant interest for its regenerative properties and potential benefits in medical research purposes

This microbial shift disrupts multiple gutbrain pathways simultaneously: these shifts coincided with gut barrier disruption (elevated serum endotoxin), triggering elevated hippocampal cytokines (IL-6, TNF-), which in turn suppress Tph2 expression and induce Tph2 hypermethylation (suggesting neuroinflammation and serotonergic suppression), ultimately manifesting as anxiety and depression-like behaviors (Buchenauer et al., 2023)

Each of those symptoms can occur either alone or with others