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doi:10.1016/j.cmet.2021.09.001 [Elsevier] Chen P, Poddar R, Tipa EV, et al

In cases where hypersensitivity is confirmed, desensitization protocols have been developed to allow patients to continue receiving necessary vitamin B12 supplementation safely

This absence of data is itself clinically significant it means that any combined use would occur without a formal safety profile for this specific pairing

Related compounds like Semaglutide have been used for over five years without a defined endpoint

Moreover, tirzepatide elongated with exenatide (2939) would most likely show no evident effect