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To evaluate semaglutide's impact on anxiety-like behavior, the assessment was conducted 24 h after the final drug administration
Liraglutide ameliorates renal injury in streptozotocininduced diabetic rats by activating endothelial nitric oxide synthase activity via the downregulation of the nuclear factor-B pathway
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Furthermore, in another study [47, 60], one semaglutide analogue demonstrated a binding affinity to GLP-1R that is more than two orders of magnitude (113.3 times) higher than native semaglutide, achieving a K d of 3.0 10 8 M compared to the K d of 3.4 10 6 M for native semaglutide
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