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Subsequently, other large clinical trials were published showing cardiovascular risk reduction with modern GLP-1 analogues: In the SUSTAIN-6 trial (semaglutide 1/week 0.5 or 1 mg s.c.), the rate of 3-point MACE decreased mainly because of significant reduction in cerebral strokes, but the rate of cardiovascular death or all-cause mortality did not decrease [5,9]

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