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Old standbys still help, too, like physical therapy, over-the-counter (OTC) anti-inflammatory medications, ice compresses, or topical OTC therapies like Biofreeze

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Upon reperfusion, the sudden influx of oxygen triggers enzymatic systems such as xanthine oxidase, NADPH oxidase, and mitochondrial electron transport chains, significantly enhancing ROS production 3

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M.et al (2015)

Severity: In the most severe phase it was really painfull and difficult to straighten out the arm after prolong perionds of it being in flexed position