Maternal metabolic changes during late gestation-reduced -1-acid glycoprotein, increased cardiac output, and diminished hepatic clearance-can amplify free-fraction exposure
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Once your dose increases, that price goes up, often quite a lot
*Redox Biology*, 10, 274-284
Mouse models allow elegant mechanistic dissection, but the complexity of human MASHespecially in the context of metabolic heterogeneitydemands cautious interpretation