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Only seven genes were significantly upregulated and four were significantly downregulated in aUC compared to control undifferentiated spheroids (Log 2 FC 1, FDR P 0.1, Supplementary Data 1)

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Before in vitro infection, PBMCs were rested overnight in the 24-well plate in a cell incubator at 37C with 5% CO 2

P = 0.0006), and dulaglutide in REWIND trial (HR 0.88

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