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In: FeingoldKRAnawaltBBlackmanMRBoyceAChrousosGCorpasEet al, editors

Our Take Perimenopause isn't just "a phase", it's a full-system shift

Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A

Profound Fatigue and Low Energy: By transporting fatty acids into the mitochondria and directly feeding the Krebs cycle with fumarate, L-Carnitine Fumarate significantly increases cellular ATP production, addressing the root metabolic cause of systemic exhaustion

However, it's important to note that the trial did not meet its primary endpoint of fibrosis improvement, and semaglutide is not FDA-approved for the treatment of NASH or metabolic dysfunction-associated steatohepatitis (MASH)

Trials aiming for glycemic equipoise should appraise the long-term effects of GLP-1 RAs on coronary events independent of glycemic control