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Retatrutide (LY3437943) represents a paradigm shift from dual GLP-1/GIP agonists to a triple-receptor agonist , uniquely targeting GIP, GLP-1, and glucagon receptors
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By 5 mg, the sustained signal approaches the peak produced by a large meal. In diabetes trials, every dose improved insulin sensitivity while reducing the amount of insulin needed. GIP also activates an anti-nausea circuit in the brainstem, which helps offset some of the gastrointestinal burden created by GLP-1. GLP-1R: appetite, tolerability, and heart rate The GLP-1 arm carries appetite suppression, slower stomach emptying, most nausea, and part of the heart-rate signal
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