If "mitochondrial signaling in aging" is the framing, MOTS-c is the literature favorite
Nat Commun 16(1):7233 Yang L, Lin Z, Mu R, Wu W, Zhi H, Liu X et al (2024) Neurons enhance bloodbrain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion
Semaglutide is simpler with fewer adjustments, while Retatrutide may need careful monitoring
10.1093/nar/19.4.939 82 HayanoM.YangW
Kurt A, Tumkaya L, Turut H, et al
In addition, glutathione has been shown to be a significant factor in the excretion of heavy metals such as mercury, cadmium and arsenic