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Independent research groups outside the original Sikiric-Seiwerth laboratory have published on the musculoskeletal soft-tissue findings, providing cross-laboratory replication of the core repair-model claims (PMID 30915550)
In the present study, DCFH fluorescence levels were consistently higher in the VPA group compared to the CT group in the cerebellum, hippocampus, posterior cortex, and striatum, indicating increased oxidative stress and supporting the effectiveness of the VPA-induced animal model
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While its expression pattern varies across tumor types, CHAC1 is frequently upregulated in aggressive malignancies, such as breast and ovarian cancer, where it correlates with advanced tumor differentiation and potentially serves as a prognostic marker
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