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However, despite previous reports on the potential advantage posed by GLP1-based multi-agonists in the management of obesity and metabolic disease, as recently exemplified by the dramatic body weight-lowering actions of the GLP1/GIP dual agonist, tirzepatide 47 , to our knowledge, no study has addressed to date the pharmacological characterization of GLP1-based unimolecular multi-agonists for management of reproductive and metabolic alterations of PCOS, using suitable preclinical models, as pre-requisite for their application in clinics

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To assess the Kir6.1 immunofluorescence intensity profiles, PDGFR immunostaining was used as a reference point to localise the cell surface

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But I think I think this is why conversations like this are so [00:32:00] important because if we start voicing now that we want to see that research, perhaps we can get it sooner

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