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L-cells are of the open type with apical processes extending towards the gut lumen with secretory granules in the basolateral pole where they can be released and their secretory material enter capillaries
This is especially important in tissues with high energy demands, such as the heart, skeletal muscles, and liver
They ferment the leftovers, especially foods high in sulfur, like eggs, red meat, and cruciferous vegetables This process produces hydrogen sulfide as waste
You may recognize some of the most common GLP-1 drugs by name: Semaglutide: Sold under the brand names Ozempic, Wegovy and Rybelsus Liraglutide: Marketed as Victoza and Saxenda Tirzepatide: Known as Mounjaro and Zepbound While originally developed for diabetes and weight management, GLP-1s may also have effects on the brain and nervous system
Victoza has some common side effects
FDA approves Wegovy for MASH
