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Intriguingly, a post hoc analysis of a phase 2 clinical trial revealed that dulaglutide treatment resulted in reductions in apoC-III and apoB levels without impacting serum LPL level, whereas treatment with tirzepatide showed a dose-dependent increase in serum LPL activity while concurrently reducing apoC-III and apoB levels (180)

[16] [48] [90] However, the quality of evidence for these findings is low and is consequently reflected in the AASM's conditional recommendation for dextroamphetamine as a treatment option for narcolepsy

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Both compounds are valuable additions to the metabolic research toolbox