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Topical application of a glutathione amino acid precursor formulation to ex vivo skin samples prior to UVB irradiation led to a significant suppression of cyclobutene pyrimidine dimers (CPD), markers of DNA damage
Annals of Allergy, Asthma & Immunology
ANOVA was used to compare UCAI with LPO, GSH, catalase and SOD
To determine if the increase in enzymatic activity in infested susceptible plants was due to increased gene expression, qPCR was again carried out to determine the levels of transcripts encoding glutathione reductases
The growth medium was then replaced with a fresh medium
IFN-, in turn, induces keratinocytes to highly express CXCL9/CXCL10 through the JAK-STAT pathway, recruiting more autoreactive CD8 T cells and forming a vicious cycle of oxidative stress-immune attack (Figure 1)
