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Injections aren't the only route, either

GLP-1 headaches are common during the adjustment period

This likely plays a role in insulin resistance.[ref] A 2025 study showed that HMGCR is a regulator of GLP-1 secretion.[ref] GLP-1 receptor agonists, which mimic higher GLP-1 levels, are associated with improved cognitive function.[ref] Recap: Statin use is associated with a higher risk of developing type 2 diabetes, which itself can impair cognitive function

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Sports Medicine

In contrast, participants relying solely on lifestyle changes lost only 2.4%