Neuropathy involves both microvascular nerve ischemia and direct Schwann cell/neuronal glucose toxicity
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[57] Inflammation and oxidative stress [edit] In metabolic conditions like obesity and diabetes, chronic inflammation and oxidative stress drive cellular damage and insulin resistance
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Pak J Med Sci 24(6):813820 Huang Z, Li S, Fan W, Ma Q (2017) Transforming growth factor 1 promotes invasion of human JEG-3 trophoblast cells via TGF-/Smad3 signaling pathway