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It sounds pretty worrying
Histidine, with its pKa near 6.5 and capacity to exist in two imidazole tautomers, is uniquely positioned to function as both a general acid and general base at physiological pH, accounting for its prevalence in enzyme active sites
Sep 2013;1(5):749-57
In another study that examined the molecular mechanisms behind the effects of liraglutide on oxidized low-density lipoprotein in endothelial cells [68], liraglutide was found to suppress LDL-induced immune cell adhesion to the endothelial cells by inhibiting the expression of vascular adhesion molecules including E-selectin and VCAM-1 both of which have been related to the development of atherosclerosis [68,69,70,71] (refer to Figure one)
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