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Oral administration at 100150mg to match subcutaneous bioavailability doubles the per-dose cost, which influences protocol design when budget constraints exist

However, a consideration was raised by a commentary on this paper (99)

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Binding of ZAP-70 to Phosphorylated T-Cell Receptor Zeta and Eta Enhances Its Autophosphorylation and Generates Specific Binding Sites for SH2 Domain-Containing Proteins