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One proposed mechanism of action is that stimulation of 5-HT 2C receptors in pro-opiomelanocortin (POMC) neurons within the arcuate nucleus of the hypothalamus leads to increased release of -MSH (Garfield and Heisler, 2009)

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When theyre activated, dopamine signaling seems to shift a bit

The neurons in these areas that express the GLP-1 receptor interact with GLP-1 analogs, indirectly influencing central circuits

Ji R, Smith M, Niimi Y, Karakatsani ME, Murillo MF, Jackson-Lewis V, et al