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Oxidative stress also activates the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 to regulate the expression of genes that control antioxidant, inflammatory and immune system responses, facilitating GSH activity

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In clinical practice, during chemotherapy for patients with impaired liver function, the liver-protective effect of GSH is often prioritized, while the potential risk of chemotherapy resistance due to its non-standardized intake is frequently overlooked

doi: 10.3389/fphar.2023.1222195 Received 14 May 2023 Accepted 26 June 2023 Published 18 July 2023 Volume 14 - 2023 Edited by Wirginia Kukula-Koch, Medical University of Lublin, Poland Reviewed by Armando Caceres, Galileo University, Guatemala Laiba Arshad, Forman Christian College, Pakistan Poonam Arora, Shree Guru Gobind Singh Tricentenary University, India Updates Copyright 2023 Yuandani, Jantan, Haque, Rohani, Nugraha, Salim, Septama, Juwita, Khairunnisa, Nasution, Utami and Ibrahim

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