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In these studies, signatures for each disease were derived using several publicly available gene-expression datasets and queried in the CMap

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In addition, individuals who may be vitamin K deficient due to liver failure, those with a propensity to bleed (e.g., bleeding peptic ulcers), and those with inherited bleeding disorders (e.g., hemophilia) or a history of hemorrhagic stroke, should not take -tocopherol supplements without close medical supervision because of the increased risk of hemorrhage (119, 128)

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