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Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human
For a deeper dive into how peptides work generally, see our complete peptide guide
PubMed laboratory research record [PMID: 39043357] PubMed record related to this compound for laboratory literature review
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Similar to other peptide-bound GLP-1R structures 13,16 , exendin-4 and oxyntomodulin adopted a continuous alpha helix, with their C-terminus bound within the ECD and their N-terminus bound deep within the TMD forming extensive interactions with residues within TM1, TM2, TM3 TM5, TM6, TM7 and ECL2 (Figs
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