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In 1929 Castle observed that gastric juice contained a protein he called intrinsic factor (IF), which enhanced the clinical effects of extrinsic factor (32)
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In addition, GLP-1 can reduce liver cholesterol accumulation by inhibiting SREBP2 and PCSK9, and reduce liver bile acid synthesis by weakening the negative feedback inhibition of bile acid after inhibiting FXR
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Cell 117 , 285297 (2004)
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